L-HPC
Disintegrant with Binding Properties
(Low - Substituted Hydroxypropyl Cellulose; NF)
|
Grade |
Particle Size |
HydroxypropoylContent (%) |
Method of Appplication |
| LH |
11* |
180 µ m on: = 0.5%, 150 µ m pass: = 98% |
10.0 - 12.9 |
Direct Compression |
| 20 |
106 µ m on: = 1.0%, 75 µ m pass: = 90% |
13.0 - 16.0 |
Direct Compression
Wet granulation
Pellet extrusion |
| 21 |
10.0 - 12.9 |
| 22 |
7.0 - 9.9 |
| 31 |
75 µ m on: = 5.0%, 45 µ m pass: = 50% |
13.0 - 16.0 |
Wet granulation
Pellet extrusion |
| 32 |
10.0 - 12.9 |
| 33 |
7.0 - 9.9 |
Note: LH- 11 is especially useful to prevent capping.
METOLOSE
Binder and Thickening Agent
(Hydroxypropyl Methylcellulose 2208, 2906, 2910; USP & Methylcellulose; USP)
|
Type |
Viscosity*(Grade)(cP) |
Substitution Type |
Methoxyl Content (%) |
Hydroxypropoxyl Content (%) |
| METOLOSE |
SM |
4 15 25
100
400 1500 4000 |
(Methylcellulose) |
27.5 - 31.5 |
- |
| 60SH |
50 4000 10000 |
2910 |
28.0 - 30.0 |
7.0 - 12.0 |
| 65SH |
50 400
1500 4000 |
2906 |
27.0 - 30.0 |
4.0 - 7.5 |
| 90SH |
100 400
4000
15000 100000 |
2208 |
19.0 - 24.0 |
4.0 - 12.0 |
Note: 2wt. %aqueous solution at 20 Degree according to the USP measuring method.
METOLOSE SR grade
Binder for Sustained Release Usage
(Hydroxypropyl Methylcellulose 2208; USP)
|
TYPE |
VISCOSITY (Grade) (cp) |
Substitution Type |
Methoxyl Content (%) |
Hydroxypropoxyl Content (%) |
| METOLOSE |
90SH |
4000SR
100000SR |
2208 |
22.0 - 24.0 |
8.0 - 10.0 |
Note:
2wt. % aqueous solution at 20 Degree C according to the USP measuring method.
The degree of substitution and powder properties (i.e. particle size etc.) of METOLOSE SR grades are controlled to a limited range which is suitable for sustained release preparations from the viewpoint of functionality and processability.
METOLOSE SR grades are suitable for direct compression and wet granultion. |
